The process of serially diluting solutions in microplates is common for many assays including preparation of dose response curves for IC50, drug efficacy testing, etc. There are many critical steps to this type of assay that are carefully controlled, such as contaminant quantitation and prospective drug concentration.
As more and more researchers move to sub-10 μL reaction volumes in their genomics workflows, it will become more critical than ever before to ensure highly precise liquid handling within these volume ranges. The MANTIS can be easily added to any traditional liquid handling workstation in order to obtain CV’s under 2% across the entire pipetting range.
You wouldn’t bake a cake without mixing the ingredients first, yet when important assays are being conducted the liquids dispensed into a microplate are often assumed to have mixed through simple diffusion or after only a cursory agitation of the plate.
Takeda California uses the non-contact ATS-100 Acoustic Transfer System in various compound management liquid handling activities in support of drug discovery processes. It is widely accepted that proper quality assurance is important for accurate and efficient processes - and proper calibration of automated liquid handling instruments is a key component of such quality assurance.
Acoustic drop ejection (ADE) technology enables low- nanoliter transfers for high-throughput screening applications. Verifying the absolute transferred volume and the well-to-well reproducibility of the ADE liquid handler is important for quality control, but there are few methods available that can quickly and accurately interrogate dispensed volumes in this range.
While robotic liquid handlers have allowed increased testing capabilities in the laboratory, concerns over protocol, accuracy and suitability still remain. Laboratories around the world have turned to liquid […]
Scientists typically optimize assay parameters first, then select an automated liquid handler using default parameters during transition to an automated platform. This study illustrates the importance of optimizing both the assay and any associated liquid handling steps with the goal of minimizing variability.