September 23, 2013

3 Tips to Aid Assay Transfer

These guidelines can improve the success of assay transfers within and between laboratories Ensuring that assays give the same results on different platforms or in different […]
September 28, 2013

Accuracy Matters When Quantitative, Manually-pipetted Assays Graduate to Automation

A Story in Diagnosing and Troubleshooting Abstract It is often the case that assays are initially performed on the benchtop  using handheld  pipettes  before they graduate, […]
September 28, 2013

Accuracy of Serial Dilutions Tested Over a Large Dilution Range

The process of serially diluting solutions in microplates is common for many assays including preparation of dose response curves for IC50, drug efficacy testing, etc. There are many critical steps to this type of assay that are carefully controlled, such as contaminant quantitation and prospective drug concentration.
August 29, 2018

An Assessment of the Volumetric Performance of the The MANTIS® Liquid Handler Using the Artel MVS® Multichannel Verification System

As more and more researchers move to sub-10 μL reaction volumes in their genomics workflows, it will become more critical than ever before to ensure highly precise liquid handling within these volume ranges. The MANTIS can be easily added to any traditional liquid handling workstation in order to obtain CV’s under 2% across the entire pipetting range.
September 24, 2013

Artel MVS as a Tool for Measuring Liquid Mixing Efficacy in Microplates

You wouldn’t bake a cake without mixing the ingredients first, yet when important assays are being conducted the liquids dispensed into a microplate are often assumed to have mixed through simple diffusion or after only a cursory agitation of the plate.
June 5, 2014

ATS-100 Acoustic Transfer System calibration using Artel MVS and DMSO Range E dye: A practical approach to developing calibration curves

Takeda California uses the non-contact ATS-100 Acoustic Transfer System in various compound management liquid handling activities in support of drug discovery processes. It is widely accepted that proper quality assurance is important for accurate and efficient processes - and proper calibration of automated liquid handling instruments is a key component of such quality assurance.
September 28, 2013

Automation of Nanoliter Volume Transfers

Doing More With Less Introduction To facilitate the discovery and refinement of lead compounds, our laboratory known as the Facility for Automation and Screening Technology (FAST) […]
September 30, 2013

Best Practices for Assessing Nanoliter Transfer Performance for Labcyte Echo Liquid Handlers

Acoustic drop ejection (ADE) technology enables low- nanoliter transfers for high-throughput screening applications. Verifying the absolute transferred volume and the well-to-well reproducibility of the ADE liquid handler is important for quality control, but there are few methods available that can quickly and accurately interrogate dispensed volumes in this range.
September 24, 2013

Can You Trust Your Robot?

While robotic liquid handlers have allowed increased testing capabilities in the laboratory, concerns over protocol, accuracy and suitability still remain. Laboratories around the world have turned to liquid […]
February 14, 2019
Coupling assay design and process optimization toward minimizing variability

Coupling assay design and process optimization toward minimizing variability

Scientists typically optimize assay parameters first, then select an automated liquid handler using default parameters during transition to an automated platform. This study illustrates the importance of optimizing both the assay and any associated liquid handling steps with the goal of minimizing variability.