January 6, 2017

Improving Assay Performance Using a Process Optimization Approach

This poster presents two major findings. First, how to study liquid handlers as part of a system within the context of the assay being optimized. Second, it was possible to further optimize the overall performance of the assay by not only optimizing the liquid handlers, but by choosing the correct liquid handler-reagent pairing.
March 16, 2016

Does weather affect pipetting? YES!

This study uses a two factor design (temperature and humidity) to investigate volumetric performance (precision and trueness) at environmental conditions from 15 °C to 30 °C and 30% to 80% relative humidity. Nine environmental conditions were tested, the mid point, four corner cases and four edge cases. Replicate testing was performed at the mid point and corner cases.
February 3, 2016

Standardization of Tecan Freedom EVO liquid handling platforms using the QC Kit

This tutorial presented by Artel and Tecan will discuss the importance of standardization of these critical laboratory tools and how to control the performance of Tecan® Freedom EVO® liquid handling platforms using the Tecan QC Kit. In addition, we will summarize the results of an in-depth study on the effects of environmental conditions on liquid handler performance. This tutorial will illustrate how you can be confident that 1 µL is really 1 µL regardless of where, when or with what liquid handler the volume was dispensed.
February 3, 2016

Introducing New Technology for Liquid Handling Quality Assurance

Controlling and optimizing the liquid handling component of drug discovery and other life science laboratory processes can save valuable time and resources. This tutorial introduces new technology from Artel, enabling fast, in-process volume determination of any liquid or solid dispensed or stored in microplate wells. Accurate, reliable, and repeatable volume measurements are achieved by applying pressure to individual sealed wells, regardless of the shape of the well, type of plastic, or density of the contents.
April 7, 2014
Effect of Liquid Handler Accuracy on Assay Perfromance

Effect of Liquid Handling Accuracy on Assay Performance

This study illustrates how optimization of both liquid-handling accuracy and precision is critical to assay performance. The study was designed to examine (1) liquid-handling performance and […]
March 15, 2014

Lab Report 1: How Many Data Points

Human beings are creatures of habit We often seek stability and continuity and are wary of change. However, inspection, evaluation, and subsequent change are often necessary […]
October 28, 2013

Five Good Reasons: the argument for pipetting technique training

Liquid handling quality assurance is a critical component of an effective laboratory quality program. While quality assurance efforts in liquid handling typically place much emphasis on pipette calibration, repair, and maintenance, ensuring […]
September 30, 2013

Optimize Volume Transfer Methods to Avoid Reagent Concentration Error

Laboratories utilizing liquid handling devices appreciate the efficiency benefits that these important instruments provide. Fast and repeatable volume transfers, however, do not always contribute to accurate assay results. Assays are dependent on reagent concentrations and reagent concentrations are volume- dependent.
September 28, 2013

Accuracy Matters When Quantitative, Manually-pipetted Assays Graduate to Automation

A Story in Diagnosing and Troubleshooting Abstract It is often the case that assays are initially performed on the benchtop  using handheld  pipettes  before they graduate, […]
September 28, 2013

Accuracy of Serial Dilutions Tested Over a Large Dilution Range

The process of serially diluting solutions in microplates is common for many assays including preparation of dose response curves for IC50, drug efficacy testing, etc. There are many critical steps to this type of assay that are carefully controlled, such as contaminant quantitation and prospective drug concentration.