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10 Tips To Improve Your Pipetting Technique
The experts at Artel demonstrate, in detail, how your pipetting technique and the performance of your pipette can be significantly improved.
Artel Lab Report eBook – your guide to liquid handling data quality
This eBook is intended to help users of pipettes and automated liquid handling systems and covers topics ranging from establishing tolerance limits, to the impact of pipetting technique.
Minimize Variability in your NGS assay
This webinar presents methodologies for increasing throughput, lowering costs and improving reproducibility for your automated assays.

Liquid handling considerations for automating your NGS workflow

By Hentz, N., Graves, J
In this webinar, Dr. Nathaniel Hentz and Jason Graves will highlight their approach for addressing NGS workflows and present methodologies for improving DNA normalization, ensuring…

Genomics workflow optimization: Overcoming barriers for successful automation

By Enea, N.
Many labs turn to automation to increase throughput, lower costs, and reduce operator-related errors. Transferring a manual, bench-top assay to an automated platform, however, is…

Webinar: Understanding Barriers to Successful Assay Optimization with an Eye Toward Automation

By Hentz, N., Ivory, W.
In this expert on-demand webinar, learn about the most common barriers to successful assay optimization and the importance of monitoring workflows The liquid handling component…

Coupling assay design and process optimization toward minimizing variability

By Hentz, N.
Overview Scientists typically optimize assay parameters first, then select an automated liquid handler using default parameters during transition to an automated platform. This study illustrates…

Genomics workflow optimization: Coupling assay development and process characterization toward automation

By Hentz, N., Kitchener, B.
Overview Many labs turn to automation to increase throughput, lower costs, and reduce operator-related errors. Transferring a manual, bench-top assay to an automated platform, however,…

An Assessment of the Volumetric Performance of the The MANTIS® Liquid Handler Using the Artel MVS® Multichannel Verification System

By Allen, K., Rawlins, T., Rodinov, D.
Introduction Since the inception of the variable volume pipette in the 1960s, researchers have been sacrificing the precision of their liquid transfers for ease of…

I-DOT One & the Artel MVS®

By Graeve, M., Laske, C., Schork, S.
Abstract The Immediate Drop on Demand Technology (I-DOT) is a new approach for non-contact low volume dispensing, developed at the Fraunhofer Institute for Manufacturing Engineering…

Low Volume Liquid Measurement Testing with Beckman Coulter’s Biomek i-Series Automated Workstation using the Artel Multichannel Verification System (MVS®)

By Campbell, D.
Note: This application note has been formatted to fit this screen. Download the published version at the bottom of this page. Abstract This application note provides…

Optimizing Accuracy Performance of a Thermo Scientific Matrix WellMate Dispenser Using the Artel MVS®

By Albert, K.
Note: This application note has been formatted to fit this screen. Download the published version at the bottom of this page. Abstract This application note discusses…

Ten Tips for Proper Pipetting

By Carle, B.
Overview Like most recurring or common tasks, pipetting is sometimes taken for granted. But since even minor variation in operating technique can produce measurable errors…

Improving Assay Performance Using a Process Optimization Approach

By Hentz, N., Avis, E.
Abstract High throughput screening (HTS) campaigns often rely on a single test to make a decision to proceed onto the next step. Minimizing assay variability…

ISO standards for assessing the volumetric performance of automated liquid handling systems

By Rodrigues, G.
Simplify method transfer and reduce compliance risk by using an international standard This presentation covers how volumetric performance and regulatory standards overlap, focusing on the biggest…

Understanding Precision, Trueness and Accuracy

By Rodrigues, G.
Three brief videos break down recently-revised standards terminology to help you understand the background behind the change, and the importance of correct usage. Precision, trueness…

Does weather affect pipetting? YES!

By Rodrigues, G., Avis, E., Price, A., Gerber, V.
Note: This poster has been formatted to fit this screen. Click here to download the published version. Introduction Liquid handler performance can be optimized by adjusting…

SURVEY REPORT: Data quality, variability, and reproducibility

By Artel
From the Reproducibility Initiative to F1000 Research's Preclinical Reproducibility and Robustness channel, much attention in the life science community has been focused on study reproducibility.…

Volumetric Performance Assessment of Automated Liquid Handling Systems with ISO IWA 15

By Carle, A.B., Rodrigues, G.
Description The use of Automated Liquid Handling Systems (ALHS) is nearly ubiquitous in modern life sciences, clinical, forensic, as well as other analytical laboratories. These…

Standardization of Tecan Freedom EVO liquid handling platforms using the QC Kit

By Albert, K., Rodrigues, G., Sullivan, T.
Description Variability across liquid handling platforms of the same make and model is often uncharacterized and can lead to erratic results from instrument to instrument…

Introducing New Technology for Liquid Handling Quality Assurance

By Gigante, B., Bradshaw, J.
Description Controlling and optimizing the liquid handling component of drug discovery and other life science laboratory processes can save valuable time and resources. This tutorial…

Artel Lab Report eBook – your guide to liquid handling data quality

By Artel
When testing accuracy, precision and trueness of liquid handling instruments, how many data points should you test for each volume? Does pipetting technique impact data…

In-House Pipette Calibration: The Lean Way

By Artel
Situation When your tests can impact criminal cases, help labs confirm that a sample belongs to a specific patient, or help verify or refute paternity,…

XenoTech Ensures Quality

By XenoTech
Achieving Reliable, Trustworthy Data for the Drug Discovery and Development Industry A drying pipeline. Exorbitant costs. High attrition rates. Over the past decade a lot…

Best Practices for the Use of Micropipettes

By Carle, B., Rodrigues, G., Rumery, D.
Introduction Mechanical action micropipettes are ubiquitous in laboratories and are used for many routine tasks, including the quantitative measurement and dispensing of analytical samples and…

Verifying the accuracy and precision of liquid handlers is essential for assay reliability

By Schork, S. - Artel, Jenkins, J., Schenker, B. - TTP Labtech
Introduction Assay-ready plates are becoming key to maximizing throughput and assay robustness for many HTS departments. These plates contain test compounds prepared at specific concentrations…

Environmental Studies Using the Tecan QC Kit and an Automated Liquid Handling System

By Rodrigues, G., Avis, E. - Artel, Price, A., Gerber, V. - Tecan
Introduction Liquid handler performance can be optimized by adjusting system operating parameters, but the effect of environmental conditions on liquid handling quality is often underappreciated.…

Minimizing Liquid Delivery Risk: Pipettes as Sources of Error

By Curtis, R.
Liquid delivery is one of the most common processes in life science laboratories, from drug discovery and compound management laboratories to analytical chemistry and genomics/proteomics…

Minimizing Liquid Delivery Risk: Automated Liquid Handlers as Sources of Error

By Albert, K.
The use of automated liquid handling equipment to rapidly test and reproducibly screen thousands of compounds has become an essential component to life science laboratories…

Best Practices for the Use of Micropipets

By Carle, B.
Note: this publication has been modified to fit this page. Download the published version.  Every day, air-displacement pipets are used to quantitatively dispense sample and…

ATS-100 Acoustic Transfer System calibration using Artel MVS and DMSO Range E dye: A practical approach to developing calibration curves

By Scheibe, D., Palan, J., Khovananth, K.
Overview The ATS-100 transfers one or more droplets of a given fixed size (e.g. 1nl, 2.5nl, 10nl, etc.) in multiples necessary to attain the desired…

Improved Pipetting Technique: An “Out-of-the-Box” Solution to Reduce Manual Pipetting Errors

By Artel
Situation Time is money in the field of drug discovery and development. Because it takes as long as 10 years to bring a new therapeutic…

Effect of Liquid Handling Accuracy on Assay Performance

By Hentz, N., Knaide, T.
This study illustrates how optimization of both liquid-handling accuracy and precision is critical to assay performance. The study was designed to examine (1) liquid-handling performance…

Lab Report 1: How Many Data Points

By Artel
Human beings are creatures of habit We often seek stability and continuity and are wary of change. However, inspection, evaluation, and subsequent change are often…

Lab Report 2: Impact of Pipetting Technique

By Artel
The pipette is a reliable precision instrument that has been used and trusted for many years. However, as with many forms of instrumentation, a pipette…

Lab Report 3: Pipette Use and Ergonomics

By Artel
Any work environment including the laboratory, can be a source of ergonomic stress. Laboratorians that use pipettes frequently may find not only their health, but their…

Lab Report 4: Defining Accuracy, Precision and Trueness

By Artel
Language influences thinking and careful use of words when evaluating data allows us to understand how best to improve laboratory accuracy. Accuracy is a particularly important…

Lab Report 5: Setting Tolerances for Pipettes in the Laboratory

By Artel
The performance of mechanical action pipettes must be tested periodically to ensure accurate liquid delivery. The results of such testing then may be compared with pre-established…

Lab Report 6: Calibration Frequency for Pipettes

By Artel
Understanding how pipettes fail Silent Failures Mechanical action pipettes, unlike the original glass pipette, contain many internal parts. Some pipette failures are evident, either to…

Pipetting Characteristics of Serum and Serum-like Solutions versus Water

By Bradshaw, J., Curtis, R., Parshley, R., Flumerfelt, L.
Introduction Many types of chemical and biological analyses, which are core to bio-pharmaceutical laboratories, are based upon analytical techniques involving accurate delivery of liquid components. …

Reducing Costs by Improving Liquid handling

By Campbell, D., Knaide, T. - Artel, Roby, K. - Beckman Coulter
Abstract Lowering costs and reducing repeat testing are common interests in all areas of life science. Removing sources of variability from test processes reduces error…

Pipetting Comparison of DMSO Versus Aqueous Solutions as Measured Using Dual-Dye Technology

By Parshley, R., Bradshaw, J., Albert, K.
 Abstract DMSO (dimethyl sulfoxide) has become one of the most important solvents used throughout pharmaceutical and life science laboratories. This is particularly true for high-throughput…

Accuracy and Precision in Low Volume Liquid Transfers

By Tam, S., Rodrigues, G. - Artel, Forbush, M. - EDC Biosystems
Introduction Acoustic transfer systems operate by ejecting a rapid fire stream of tiny discrete droplets, with each droplet adding a few nanoliters to the total…

Measuring the Performance of Microplate Dispensers as Part of a Method Scale-up Process

By Knaide, T., Albert, K., Avis, E.
Abstract Liquid handling is often an overlooked and underappreciated factor in the success of assay transfer from the bench to automation. Often as part of…

DMSO Sample Solution for Liquid Handler Performance Verification

By Parshley, R.
Dimethyl sulfoxide (DMSO) has become one of the most important solvents used for high-throughput screening (HTS) and compound management applications due to its ability to…

Five Good Reasons: the argument for pipetting technique training

By Carle, Bjoern
Liquid handling quality assurance is a critical component of an effective laboratory quality program. While quality assurance efforts in liquid handling typically place much emphasis on pipette calibration, repair, and…

Performance assessment of the VIAFLO 96 handheld 96-channel pipette

By Beier, M., Parshley, R.
Introduction The standard method of determining a pipette’s liquid delivery performance is measuring the weight of the transferred liquid. Every channel of a multichannel pipette…

8 Easy Steps for Performing Pipette Preventive Maintenance

By Artel
Pipettes are precision devices that require care for consistent results. Performing preventive maintenance routinely will help to minimize malfunctions and keep your instruments in good operating condition.…

Lab Report 7: Facilitating Assay Transfer by Controlling Liquid Handling Variables

By Artel
Assay transfer is one of the most complex activities in laboratories today. Successful assay transfer ensures that new results are comparable to historical data. Whether…

Artel Extreme Pipetting Expedition: Measuring the Impact of Common Environmental Conditions on Laboratory Data Integrity

By Rodrigues, G.
A team of scientists journey to extreme locations to demonstrate how even the most typical laboratory conditions can wreak havoc on pipette accuracy. While pipetting…

Extreme Pipetting IV: It’s Not the Heat, It’s the…

By Rumery, D.; Carle, B.
Pipettes perform exceptionally well in high humidity Fresh on the heels of Mission 3 at the stiflingly hot Death Valley National Park, the Artel Extreme…

Preventing Pandemics – The Global Influenza Threat

By Hentz, N.
Over the years, influenza has taken the lives of millions. While vaccines are helping to reduce the damage caused by the virus there is still…

The eVolving Needs of Quality Assurance

By SGE Analytical Science
SGE’s revolutionary electronic syringe provides critical performance when and where it is needed in demanding QA field applications. Introducing a new method or product into…

Impact of Liquid Handling Variability on In Vitro Biochemical Assay Performance

By Hentz, N. - BTEC
A Look at Protein Binding and Enzyme Assay Classes Overview Review accuracy and precision Discuss common liquid handler QC methods Artel MVS technology description Brief…

Effect of Liquid Handling Quality Control on Biological Assay Performance

By Hentz, N. - BTEC, Knaide, T. - Artel
Introduction Automated liquid handlers have enabled dramatic improvements in the efficiency of screening the efficacy of potential new drug candidates, but just like a map…

Software System Used to Automate Equipment Performance Investigations and Improve Monitoring of Equipment at CareDx

By Butler, R., Wexler, D. - CareDx
Overview Many of the clinical laboratory workflows in use at CareDx rely heavily on Liquid Handling Instruments (LHI). As part of our Master Calibration Plan, all equipment…

Understanding Error Contribution of Liquid Handling and Analytical Equipment to Overall Assay Performance

By Bradshaw, J.
Abstract The introduction of automation and integrated analytical equipment into biology and chemistry labs has led to significant advances in testing capabilities over the past…

Effect of Liquid Handling QC on Biological Assay Performance

By Hentz, N. - BTEC
Introduction In order to obtain promising HTS candidates, high quality assays are required. Assay variability is a combination of liquid handling, biological and random variability.…

The Importance of Liquid Handling Details and Their Impact on Your Assays

By Bradshaw, J.
Introduction The introduction of automation into biology and chemistry labs has arguably lead to significant advances in testing capabilities over the past 20+ years.  Automation…

Performance Verification of CERTUS Nano Liquid Dispenser

By Schork, S. - Artel, Biegger, M., Wursten, E., Zahid, M. - Fritz Gyger AG
Abstract The need to downsize assay formats is growing, but technically it is a hard challenge for equipment manufacturers. Verification and calibration of automated liquid…

Effect of Liquid Handling Quality Control on Biological Assay Performance

By Hentz, N.- BTEC, Knaide, T. - Artel
Introduction Molecules from a high throughput screening (HTS) campaign are often selected for further development after a single interrogation. HTS groups are also constantly challenged…

Nanoliter Volume Pin Tool Transfers as Measured by a Dual-Dye Absorbance Method

By Bradshaw, J. - Artel, Chau, D., Cleveland, P. - V&P Scientific
Introduction A common trend observed in life science testing over the past several years has been the ever shrinking test volume.  Increasing costs of chemical…

Why Is My Assay Failing?

By Knaide, T., Bradshaw, J. Khovananth, K., Albert, K.
 Abstract Assays can produce unexpected or failing results for a multitude of reasons. Variability may be introduced at any point within the assay process. Some…

Is Your Automated Liquid Handler Working for Your Assays?

By Albert, K.
Uncovering Errors, Understanding Device Behavior, and Optimizing Methods Abstract The focus of this presentation is to highlight the need of ensuring quality in important assays…

Do You Really Know What Your Robot is Doing?

By Bradshaw, J., Albert, K., Knaide, T.
The Importance of Paying Attention to Liquid Handling Details Introduction The introduction of automation into biology and chemistry labs has arguably lead to significant advances…

Do Plate Readers Agree?

By Knaide, T., Bradshaw, J., Curtis, R., Ritter, G., Parshley, R.
Understanding Performance Differences between Different Plate Reader Makes and Models Introduction Multiple plate readers are often used throughout a facility to measure the response in…

Optimization of the TechElan TEOS Orbital Shaker

By Spaulding, B., Bradshaw, J. - Artel, Chang, P., Feygin, I. - TechElan
Introduction [one][one_second] Achieving optimal mixing results, especially in all the various 384-well formats, can be an elusive goal.  Artel developed a quantitative method that allows…

Transferability of Pipette Calibrations

By Carle, B., Rodrigues, G.
Introduction One of the most obvious ways to maintain quality in a laboratory setting is the regular calibration of instruments. Regardless of the measuring instrument,…

Is Your Liquid Handler Efficient at Removing Sample?

By Khovananth, K., Neilsen, J., Albert, K.
Abstract This presentation demonstrates an alternative use for the Artel MVS® Multichannel Verification System. As opposed to measuring the accuracy and precision of a volume transfer into…

Understanding Device Behavior, Optimizing Methods, and Uncovering Errors

By Carle, B., Albert, K., Bradshaw, J.
Abstract The focus of this poster presentation is to highlight the need of ensuring quality in important assays performed with automated liquid handlers. Nearly all…

The Cost of Liquid Handler QC – A Case Study

By Knaide, T., Albert, K.
Abstract As with most laboratory instrumentation, automated liquid handlers should be assessed, verified and/or calibrated on a periodic basis. When considering an appropriate quality control…

Method Validation for Beckman Coulter Liquid Handlers

By Albert, K., Knapp, L.
Abstract The use of automated liquid handling equipment to rapidly test and screen targets-of-interest has become an essential component to drug discovery. In order to…

Validation and Optimization Techniques for the PerkinElmer JANUS

By Albert, K., Patterson, M.
Abstract Users of automated liquid handlers need to ensure the accuracy and precision performance of their equipment in order to satisfy their quality system and…

Performance Optimization of Multichannel Liquid Handling Equipment and High Throughput Assays

By Albert, K., Cannizzo, J., Jordan, L., Donzel, N.
Introduction All users of automated liquid handling equipment are familiar with the need to ensure proper performance of their equipment.  But for most users, calibration…

Rapid Verification System for Critical Volume Transfers

By Albert, K., Knaide, T., Bradshaw, J., Rogers, A.
Abstract Technological advancements over the past decade have led to broad implementation of automated liquid handlers. With these systems, there has been a significant movement…

Method Validation for Caliper Liquid Handlers

By Knaide, T., Cannizzo, J., Grove, G.
Abstract All users of automated liquid handling equipment are familiar with the need to ensure proper performance of their equipment.  But for most users, calibration…

Operators as Sources of Error

By Carle, B., Vaccaro, W., Albert, K., Curtis, R., Rogrigues, G.
Improved Efficiency Through Pipetting Technique Training Introduction Data integrity and confidence  in results are critical measures of a laboratory’s quality system. No matter which tests…

Optimize Volume Transfer Methods to Avoid Reagent Concentration Error

By Albert, K.
Note: This poster has been formatted to fit this screen. Click here to download the published version. Abstract Laboratories utilizing liquid handling devices appreciate the efficiency…

Errors Associated with Pipetting of Warm and Cold Liquids

By Carle, B., Rumery, D., Davis, A., Rodrigues, G.
Introduction Many  common  laboratory  procedures  require  the handling and  quantitative  dispensing of  reagents  at  various temperatures.  Mechanical  action  micropipettes  are  most often used for this…

Best Practices for Assessing Nanoliter Transfer Performance for Labcyte Echo Liquid Handlers

By Bradshaw, J., Albert, K. - Artel, Mock, M., Shieh, J. - Labcyte
Abstract Acoustic  drop ejection (ADE) technology enables  low- nanoliter  transfers  for high-throughput screening applications. Verifying  the absolute transferred volume  and the well-to-well reproducibility of the…

Rapid Accuracy and Precision Assessment of DMSO Compound Solutions Transferred with Pocket Tips

By Albert, K., Kroncke, D.
Abstract Performing assays with liquid handling equipment to rapidly test and screen compounds is essential to drug discovery and other biopharma processes. In order to…

Verifying Mosquito Nanoliter Liquid Dispensing

By Schenker, B., Albert, K., Knaide, T.
Abstract Assay-ready plates are becoming key to maximizing throughput and assay robustness for many HTS departments. These plates contain test compounds prepared at specific concentrations…

Development of a 100% DMSO Sample Solution for Liquid Handler Performance Verification

By Parshley, R., Bradshaw, J., Rodrigues, G., Albert, K., Olson, K., Rumery, D.
Abstract DMSO (dimethyl sulfoxide) has become one of the most important solvents used for high-throughput screening (HTS) and compound management applications due to its ability…

Automation of Nanoliter Volume Transfers

By Fay, J., Williams, E., Mosser, S., Harrell, C., Calamari, A., Mullen, F., Harkins, T., Bednar, R.
Doing More With Less Introduction To facilitate the discovery and refinement of lead compounds, our laboratory known as the Facility for Automation and Screening Technology…

Quantifying the Impact of Operator Error in Pipetting

By Rumery, D., Rodrigues, G., Davis, A., Shoberg, J, Schafer, T.
Abstract Mechanical action hand-held pipettes are commonly used for transfer of microliter liquid quantities in a variety of analytical laboratories including pharmaceutical quality control, medical…

Accuracy Matters When Quantitative, Manually-pipetted Assays Graduate to Automation

By Albert, K., Knapp, L.
A Story in Diagnosing and Troubleshooting Abstract It is often the case that assays are initially performed on the benchtop  using handheld  pipettes  before they…

Accuracy of Serial Dilutions Tested Over a Large Dilution Range

By Knaide, T., Parshley, R., Bradshaw, J., Curtis, R.
ABSTRACT The process of serially diluting solutions in microplates is common for many assays including preparation of dose response curves for IC50, drug efficacy testing,…

Rapidly Quantifying Dilutions in Microtiter Plates

By Knaide, T., Bradshaw, J., Rogers, A., Albert, K.
Abstract Dilution-based volume transfer steps are commonly performed for many applications, such as dose response and detection limit testing. Because the exact concentrations of target…

10 Tips to Improve Your Pipetting Technique

By Artel
The experts at Artel demonstrate, in detail, how your pipetting technique and the performance of your pipette can be significantly improved. This series of videos covers…

Getting Back to Laboratory Basics

By School of Medical Technology
Training a New Generation on Proper Pipetting The pipette is the most universally important laboratory instrument, and liquid delivery handling is arguably one of the…

First World Standards Take Root in Haiti’s National Lab

By Haiti National Laboratory
Using Artel’s PCS, Lab Sets Sights on ISO Accreditation Taking up the Western half of Hispaniola, the island where Columbus first landed, Haiti and its…

Simple and Fast Performance Verification for Ultra-Low-Volume Liquid Handlers

By Albert, K., Lee, H.
Nanoliter Aqueous Fluid Transfers Assessed with Dual-Dye Technology Abstract Poor liquid handling performance can lead to poor assay results. When the volume verification methodology used to assess…

Understanding Method Transfer Pitfalls

By Knapp, L., Albert, K.
Accuracy Matters When Transferring a Quantitative, Bench-top Assay to Automation Introduction Assays are usually performed on the benchtop using handheld pipettes before they graduate, or transfer,…

Mobile Laboratory Gives North Carolina’s Biotech Industry a Lift

By Wake Technical Community College
Innovative Continuing Education Program Offers Workforce World-Class Training From a distance it would be easy to mistake North Carolina’s BioNetwork Mobile Laboratory for a city…

Determining Dilution Accuracy in Microtiter Plate Assays

By Bradshaw, J.T.
Description Many critical assays are based upon conducting accurate dilutions of key reagents. Accurately knowing sample concentration is critical for properly interpreting experimental results, which can only be…

On-the-Job Training That’s Not on the Job

By NC State University / BTEC
Artel Pipetting Technique Training Helps NC State Prepare FDA Inspectors and Students for the Lab With the third-largest concentration of biotechnology firms  in the United…

Dispensing Precision and Accuracy for the JANUS Varispan Workstation

By Patterson, M.
Abstract Today’s biotech, pharmaceutical, environmental, clinical research, and  agricultural laboratories employ a diversity of applications and  depend more  and  more  on automated systems to address…

Volume Verification of Hamilton MICROLAB® STAR and NIMBUS Automated Liquid Handlers

By Stewart, D., Luedke, R., Godowsky, B.
Abstract A precise and accurate  means for conducting volume verification of automated  liquid handlers is an important requirement in life science laboratories, which need to…

Using the PCS to Calibrate the Beckman Coulter Biomek 3000

By Campbell, D., Wilkinson, M.
Introduction Ensuring that pipetting devices (both manual and automated) are performing properly is often a regulatory requirement. Many of those labs that are not required…

Verifying Dispensing Performance & Optimizing Accuracy on a Redd&Whyte Preddator Nano-bulk reagent Dispenser

By Poole, R., Redd & Whyte, Albert, K., Artel
Abstract This application note discusses an approach to verify and optimize the dispensing accuracy on a Redd & Whyte Preddator dispenser using measurement information from…

Pipetting Performance Testing of a Beckman Coulter Biomek 4000

By Knaide, T., Campbell, D.
Abstract A common interest in all areas of life science: lower costs and reduce repeat testing. Removing sources of variability from test processes reduces error…

The Effects of Pipette Tip Production & Sterilization Methods on the Retention of Liquids

By Spaulding, B.W., Bradshaw, J.T., Albert, K., Campbell, D., Rodrigues, G.
Introduction Plastic pipette tips are ubiquitous pieces of labware commonly used in life science, pharmaceutical, chemistry and many other types of laboratories. Because of their…

Optimizing Accuracy Performance on a Beckman Coulter Biomek

By Albert, K.
Abstract This application note discusses one approach for optimizing pipetting accuracy on a Beckman Coulter Biomek liquid handler using MVS measurement information. Pipetting accuracy can be…

Optimizing Accuracy Performance on an Agilent Bravo Platform

By Albert, K.
Abstract This application note discusses one approach for optimizing pipetting accuracy on an Agilent Bravo liquid handler using MVS® Multichannel Verification System measurement information. Although…

Evaluation of the Eppendorf epMotion Pipetting Tools

By Lui, C., Cassidy, J., Knaide, T., Parshley, R.
Introduction With budgets forever tightening and patient samples being limited, increased efficiency and reduction of repeat testing has become a common goal of almost all…

Creating and Testing Custom Alternative Solutions

By Albert, K.
Introduction Custom test liquids using assay-specific reagents can be prepared and employed to assess volume transfer performance of a liquid handler using the Artel MVS®…

The Critical Role of Liquid Handling in Effective Assay Transfer

By Albert, K.
Top Tips to Facilitate Assay Transfer Within and Across Laboratories With the life sciences industry racing down the path towards globalization and outsourcing, the importance…

Can You Trust Your Robot?

By Knaide, T.
While robotic liquid handlers have allowed increased testing capabilities in the laboratory, concerns over protocol, accuracy and suitability still remain. Laboratories around the world have turned to…

Integration of Liquid Handler Quality Control Into the HTS Daily Routine

By Ellinger, B., Hochreiner, A., Schork, S., Wilkinson, M.
Abstract This application note describes how the MVS® Multichannel Verification System can be used to assess the performance of the liquid handlers integrated into a PerkinElmer…

Performance Qualification of an Automated Plate Washer

By Khovananth, K., Knaide, T., Albert, K.
Introduction An integral, yet often overlooked, procedure with any given assay, washing steps are vital to ensure reaction quality and integrity particularly when conducted in…

Quantifying the Impact of Pipette Tip Type Using Dual Dye Ratiometric Technology

By Knaide, T., Albert, K.
Introduction All pipette tips are not created equal, nor are all assays. Failure to use proper tips for a given type of pipette can lead…

Measuring Residual Volumes Remaining in a Plate After Sample Aspiration

By Khovananth, K., Neilsen, J., Albert, K.
Abstract The purpose of this application note is to demonstrate an alternative use for the Artel MVS® Multichannel Verification System. As opposed to measuring the…

Running MVS Volume Verifications in Batches, Storing Bar Codes, and Creating Task Templates

By Albert, K.
Introduction A Batch method, or Batch template, in MVS Data Manager version 2.2+ is a stored sequence of verification tasks comprising as many devices, plate…

Mixing Efficiency of Q-Instruments Bioshake 3000® Plate Shaker

By Knaide, T.
Introduction Mixing of solutions in 384-well microplates is a challenging, yet highly important task for many laboratories and assays. Effective mixing is of particular importance…

Volume Verification Using Any Microtiter Plate or Small Volume Container Such as a Tube or Vial

By Albert, K.
Abstract This application note discusses methods for measuring target volumes (10 nL - 200 μL) dispensed into any microtiter plate or small volume container using…

Executing an MVS Volume Verification of a Tecan EVO Using EVOware Software

By Rogers, A.
Introduction This paper describes how to run or call an Artel MVS® Multichannel Verification System volume verification from another program or application. The MVS Data Manager…

Evaluation of Forward & Reverse Mode Liquid Handling Techniques

By Knaide, T.
Introduction Traditionally, precision of volume dispensing has received more focus than accuracy, making the latter overlooked. This study highlights the importance of understanding both accuracy…

Artel MVS as a Tool for Measuring Liquid Mixing Efficacy in Microplates

By Knaide, T., Parshley, R., Wilkinson, M.
Abstract You wouldn’t bake a cake without mixing the ingredients first, yet when important assays are being conducted the liquids dispensed into a microplate are…

Errors in Liquid Delivery

By Carle, B., Rumery, D., Davis, A., Sawyer, G., Albert, K., Bradshaw, J.
The Importance of Laboratory Conditions on Pipetting [one][one_second] Many common  laboratory procedures require quantitative pipettes and mechanical action air-displacement micropipettes are frequently used for this…

Optimizing Automated Liquid Handlers

By Yandell, W., Wexler, D.
Using Longitudinal Data to Understand Performance Life science, clinical and IVD manufacturing laboratories have benefited from the recent technological advances in liquid handling instrumentation, from…

Rapid Volume Verification in High-Density Microtiter Plates Using Dual-Dye Photometry

By Knaide, T., Bradshaw, J., Rogers, A., McNally, C., Curtis, R., Spaulding, B.
The dual-dye photometric technology used by Artel's MVS Multichannel Verification System overcomes challenges associated with determining the dispensed volume within each well of a 384-well microtiter…

The Importance of Liquid Handling Quality Assurance Through the Drug Discovery Process

By Hentz, N.
The tug-of-war between quality and productivity is an issue facing all drug discovery companies, competing in a fierce race to bring breakthrough drugs to market…

Multichannel Verification System: A Dual-Dye Photometry System For Performance Verification of Multichannel Delivery Devices

By Bradshaw, J.T., Knaide, T., Rogers, A., Curtis, R.
Artel has developed the MVS Multichannel Verification System, a photometric method for verifying the performance of automated multichannel liquid delivery equipment.  On the basis of…

How It Works: Verifying Liquid Handling Instrumentation Performance

By Rodrigues, G.
Problem: Laboratories often assume that their liquid handling instruments, from pipettes to automated liquid handlers, are operating within specifications. However, because data integrity for applications, from…

Standardizing pipette calibration in a large laboratory organization results in economic and quality gains

By Pou, P.
Large laboratory organizations with many departments find it difficult to allocate responsibility effectively for quality control. While a centralized, top-down approach can simplify regulatory compliance,…

The Effect of One Microliter

By Rodrigues, G.
And Why Microliters Matter Pharmaceutical processes typically take place on the scale of gallons or liters, even tens of thousands of liters.  So why would anyone…

Liquid Delivery Accuracy Advisor: Solutions to Your Liquid Handling Issues

By Rodrigues, G.
It is absolutely critical to verify that the amount of liquid transferred from well-to-well is accurate across the plate, for all steps. Some assumptions, like…

Comparing Calibration Technologies for Liquid Handling Quality Assurance

By Curtis, R., Rodrigues, G.
The use of high-quality precision liquid handling instruments throughout the drug discovery, testing and production processes has tended to give scientists a sense of confidence…

Ratiometric Photometry for Pipette Calibration

By Rodrigues, G.
Method Critical for Low-volume Measurement For Linco Diagnostic Services (www.lincodiagnostics.com), quality assurance is critical. Performing functions such as bioanalytical services and clinical trials for pharmaceutical and biotechnology…

The Role of Automation in Liquid Delivery Quality Assurance

By Rodrigues, G.
The word “calibration” often conjures up negative images, especially in IVD development and manufacturing, where regulations mandate that laboratories and production plants have regular calibration…

Ratiometric Photometry Improves Laboratory Quality Assurance

By Rodrigues, G.
New Methodology Accurately and Precisely Verifies Low Volume Liquid Delivery Laboratories often assume that their liquid handling instruments, from pipettes to automated liquid handlers, are…

Transferability of Pipet Calibrations and Proficiency of Operators: Prerequisites for Method Validations and Method Transfers

By Rodrigues, G., Carle, A.B., Curtis, R.
Data quality and integrity are among the most important issues for any laboratory, and one of the most obvious ways to maintain quality in a…

When Times Are Tough, Train, Train, Train!

By Rodrigues, G., Vaccaro, W.
How to Implement Pipetting Technique Training to Improve Laboratory Quality Staff members are critical laboratory assets. Not only are laboratory technicians directly involved in producing…

Minimizing Liquid Delivery Risk: Pipetting Technique as Source of Error

By Vaccaro, W.
For laboratory quality assurance, all critical tasks must be standardized, including liquid handling. Laboratory liquid handling quality assurance programs commonly focus on pipette calibration, repair and…

North Carolina Department of Agriculture and Consumer Services Keeps Tainted Goods out of Consumer Reach with Artel Products and Services

By NC Department of Agriculture and Consumer Services
Laboratory Challenge With a staggering list of recently tainted food and drug products in the U.S., product safety is understandably a growing concern of American…

Pipette Calibration System Minimizes Pipetting Error, Strengthens Data Integrity

By Curtis, R.
Pipetting microliter volumes of liquid has become one of the most frequently performed laboratory procedures. The speed, convenience and cost benefits of microliter‑volume, air‑displacement pipettes drive…

US Pharmacopeia Proposes Changes to Weighing Chapters

By Rodrigues, G.
Weighing is one of the most fundamental of laboratory tasks, and careful weighing is a central pillar supporting the generation of high-quality laboratory results. New proposals…

CMS Offers EP23 as Risk-Based Option for Clinical QC Plans

By Carle, A.B.
In two memoranda dated November 4, 2011 and March 9, 2012 the US Centers for Medicare and Medicaid Services (CMS) have informed laboratories of their intention to provide a…

When Do Guidelines Become Requirements?

By Rodrigues, G.
MIQE Makes a Difference in PCR A guideline such as Minimum Information for Publication of Quantitative Real-time PCR Experiments (MIQE) is a good example of how a science-based…

New ISO Standard Answers Growing Need for Data Integrity in the Laboratory

By Rodrigues, G.
Technologies often develop more quickly than regulatory agencies can respond. This is especially true in drug discovery and development due to the rapid pace of new…

Taking Control of Your Quality Control

By Rodrigues, G.
Navigating Regulations and Standards for Liquid Delivery Verification Consider a quality control laboratory that processes 10 to 20 samples per day and releases as many…

3 Tips to Aid Assay Transfer

By Keith J. Albert, Ph.D.
These guidelines can improve the success of assay transfers within and between laboratories Ensuring that assays give the same results on different platforms or in…

Optimization of Automated Liquid Handlers

By Keith J. Albert, Ph.D.
Regular Instrument Performance Checks Help Ensure Accurate Reagent Volume Transfer Over the past 20 years, laboratories around the world have been turning to liquid handling robots to…

Climb Every Mountain: Extreme Pipetting I

By Rodrigues, G.
The Effect of Barometric Pressure on Data Integrity One cold day in early winter, a group of scientists prepare to trek to the top of…

Extreme Pipetting II: Thermal Exploration

By Rodrigues, G.; Rumery, D.
The effect of fluid temperature on data integrity After studying the effects of barometric pressure on pipette volumes atop New Hampshire’s Mount Washington—home of the…

Uncovering Dimensional Variability in Standard Microtiter Plate Types

By Bradshaw, J., Rodrigues, G., Sawyer, G., Knaide, T., Rogers, A., Sargen, C.
Introduction First created in the 1950’s, microplates have become so common place that in 2004, the Society for Biomolecular Screening (SBS) established standards defining multiple dimensions…

Cybi®-Selma – Basic Information

By Cybio
Introduction CyBi®-SELMA is a semi-automatic pipettor for quick, precise and reproducible processing of 96-well and 384-well microplates. Equipped with 96 or 384 parallel working tips…

Painless Nanoliter-Transfer Accuracy Inspection for Busy Screeners

By Albert, K., Mock, M., Shieh, J.
Abstract Acoustic droplet ejection first provided low-nanoliter transfers for high-throughput screening applications in 2004. At that time, there were no methods that could quickly and…

Measuring the Precision and Accuracy of the Cybi®-Well vario

By Undisz, K., Hanegraaff, I., Schork, S., Knaide, T.
Introduction In laboratory automation precise and accurate liquid handling over a large volume range is essential to meet the challenges of modern drug discovery and…

Extreme Pipetting III: Death Valley Data

By Rodrigues, G., Rumery, D.
The effect of dry heat on laboratory data As the Artel extreme pipetting expedition team set out for Mission 3, only one thing was certain: it…

Minimizing Liquid Delivery Risk: Laboratory Environmental Conditions as Sources of Error

By Carle, A.B.
Part 1: Barometric Pressure and Thermal Disequilibrium The first and the third article in this series focused on manually operated pipettes as sources of error,…

In Liquid Handling Quality Assurance, All That Matters is Location, Location, Location

By Rodrigues, G.
A number of high-profile drug failures and mushrooming costs have led to growing scrutiny of the pharmaceutical industry. While drug manufacturing has always faced intense…

The Use of A Dual Dye Photometric Calibration Method To Identify Possible Sample Dilution From An Automated Multichannel Liquid-Handling System

By Huijin Dong, Zheng Ouyang, Jane Liu, and Mohammed Jemal
A significant difference between the reported volumes delivered by a fluid-filled automated liquid-handling system with eight stainless steel fixed tips was observed when a gravimetric…

Verifying Liquid Handler Performance for Complex or Non-Aqueous Reagents: A New Approach

By Keith J. Albert, John Thomas Bradshaw, Tanya R. Knaide, and Alexis L. Rogers
Multichannel volume dispensing devices, such as automated liquid handlers, are widely used in drug discovery assays and other high-throughput screening processes. The performance of these…

Measuring the Accuracy and Precision of the epMotion 5070 Workstation

By Spaulding, B., Bradshaw, J., Albert, K., Eggert, H.
Introduction In response to the need to automate molecular biology methods, automated liquid handling technology has been the focus of extensive research and development. The…

Importance of Integrating a Volume Verification Method for Liquid Handlers: Applications in Learning Performance Behavior

By Keith J. Albert, John Thomas Bradshaw
Nearly all assays performed within a microtiter plate are volume dependent. In turn, all concentrations of biological and chemical components in these assays, as well…

Determining Dilution Accuracy in Microtiter Plate Assays Using Quantitative Dual-Wavelength Absorbance Method

By John Thomas Bradshaw, Richard H. Curtis, Tanya R. Knaide, and Benjamin W. Spaulding
Dilution-based volume transfer steps are commonly performed for many types of microtiter plate-based assays. Because the exact concentrations of target samples in solution are typically…

Ethanol Solutions for MVS® Volume Verifications

By Keith J. Albert, Ph.D.
Introduction Ethanol is used in pharmaceutical and other life science laboratories for innumerable experimental protocols. Ethanol is often combined and/or used as an additive in…

Glycerol Solutions for MVS® Volume Verifications

By Keith J. Albert, Ph.D.
Introduction Glycerol plays an important role in many industries and because of its physical and chemical characteristics, it is used extensively in life science industries.…

Contract Laboratory Improves Liquid Handling Quality Assurance

By LINCO Diagnostic Services
Laboratory Challenge For LINCO Diagnostic Services, a contract laboratory specializing in ligand binding assays, quality assurance is critical. Performing functions such as bioanalytical services and clinical…

MMQCI uses Artel PCS® to Strengthen Liquid Handling Quality Assurance

By Maine Molecular Quality Control
Laboratory Challenge The molecular diagnostics industry is a relatively new territory that offers much promise for early disease detection and personalized patient care. When analyzing…

Flying on Course

By FAA
FAA’s Forensic Toxicology Lab Enhances Quality and Compliance with Pipette Calibration System from Artel With a spate of recent high-profile plane crashes, there has been…

All Together Now!

By ARUP Laboratories
Standardizing Pipette Quality in a Large Laboratory Organization Results in Economic and Quality Gains Large laboratory organizations with many departments find it difficult to effectively…

Leading the Way With Accreditation in a Country of Firsts

By Patria Rivas Clinical Lab
A Beacon for Top Quality Standards in the Dominican Republic Occupying the eastern half of the West Indian island of Hispaniola, the Dominican Republic is…

Keeping Plasma Safe

By
Haematologic Technologies Inc. Implements Artel’s Liquid Handling Quality Assurance Systems to Ensure Consistent Results When platelets, red blood cells, and white blood cells are removed…

Quality Data at the Speed of Light

By SGE Analytical Science
The Artel PCS validates performance claims for SGE’s award-winning liquid dispensing instrument where all other testing methods had failed When you are in the process…

Beckman Coulter Improves Operational Qualification Program with Advanced Technology for Liquid Delivery Quality Assurance

By
Laboratory Challenge Operational qualification is important for most life science laboratories, especially those in the clinical and pharmaceutical markets, as it is used to prove…

When Analyzing Cancer at the Molecular Level, Microliters Matter

By Genomic Health
Laboratory Challenge Over 1.4 million Americans are expected to be diagnosed with cancer this year. While improvements in disease detection, diagnosis and therapies are continually…

No Room for Error in Drug Discovery Laboratory

By
Laboratory Challenge The drug discovery process often starts in a High-Throughput Screening (HTS) laboratory. Screening campaigns typically use a number of automated liquid handlers to…

Photometric Measurement of Mixing Efficiency Using The Eppendorf MixMate Plate Mixer

By Spauding, B., Bradshaw, J. - Artel, Borrmann, L., Wente, W. - Eppendorf
Abstract Efficient mixing of solution components is a critical step in the performance of certain assay types.  As more life science and pharmaceutical laboratories conduct…

Metrological Traceability of In-House Calibrations

By Rodrigues, G.
Equipment calibration is a necessary and common fact of life in regulated laboratories, and the decision on how to calibrate often begins with a simple…

Frequently Asked Questions regarding ISO 8655, pipette calibration, and Artel’s photometric method

By
The answers to these FAQ’s were developed in consultation with Dr. Burkhard Winter of the German Standards Institute DIN, and are based on definitions given…