From the Reproducibility Initiative to F1000 Research’s Preclinical Reproducibility and Robustness channel, much attention in the life science community has been focused on study reproducibility. These […]
Research shows that up to 30 percent of pipettes and other liquid delivery devices currently in service are not performing within expected tolerances at any given moment. The risk of non-performing liquid delivery devices is compounded by the ever smaller volumes typically handled in today’s laboratories. This means that volumes that are inaccurate by just a few microliters can have significant effects on results.
To reduce liquid handling error, laboratories must implement regular calibration programs and verification checks for volume transfer accuracy and precision and to quickly identify those systems that are failing. The evaluation method should be standardized, fast, easy to implement, and minimize instrument downtime and required resources.
Every day, air-displacement pipets are used to quantitatively dispense sample and reagent aliquots for reaction, routine analyses, and specialized tests. Since concentrations of biological and chemical components in the prepared samples for analyses and assays are volume-dependent, incorrectly performed pipetting steps will directly impact the transferred volumes, and hence, the test results.
Liquid handling quality assurance is a critical component of an effective laboratory quality program. While quality assurance efforts in liquid handling typically place much emphasis on pipette calibration, repair, and maintenance, ensuring […]