This presentation will address the difference in performance of a handheld micropipette when dispensing water versus various types of animal and human serum, as well as a serum-like dye solution. These differences are quantifiable and can be accounted for through careful experimentation and attention to physical pipetting details.
Lowering costs and reducing repeat testing are common interests in all areas of life science. Removing sources of variability from test processes reduces error leading to rework, lowers risk and increases reliability of results. One likely source of variability, which is easily controlled, is liquid handling.
This poster examines the differences in liquid delivery by automated liquid handlers dispensing both aqueous and DMSO-based test solutions. For the study discussed herein, an ALH was first optimized to dispense aqueous test solutions, after which these optimized aqueous method(s) were used to dispense identical target volumes of both DMSO- and aqueous-based MVS Sample Solutions into microtiter plates, which were then measured with the MVS to determine actual delivered volume.
Acoustic transfer systems operate by ejecting a rapid fire stream of tiny discrete droplets, with each droplet adding a few nanoliters to the total aliquot. This makes the system digital, in the sense that volumes can be changed by adjusting the number of droplets.
This poster presentation discusses how the measurement technology from Artel can be used to help laboratories specifically identify and troubleshoot mis-performing channels in microplate dispensers allowing users to save time and avoid costly repetitive testing.
Automated liquid handlers have enabled dramatic improvements in the efficiency of screening the efficacy of potential new drug candidates, but just like a map they need to be calibrated against a universal 'compass'.
This poster presentation describes the software system used to automate equipment performance investigations and improve monitoring of equipment. The system was designed to combine data from a variety of data sources with workflow specific logic to create a valuable data warehouse from which query and reporting tools provide actionable information about equipment performance.
The need to downsize assay formats is growing, but technically it is a hard challenge for equipment manufacturers. Verification and calibration of automated liquid handling instruments are important for applications that demand high levels of data integrity, such as drug discovery and development, proteomics, genomics, and molecular diagnostics.
Molecules from a high throughput screening (HTS) campaign are often selected for further development after a single interrogation. HTS groups are also constantly challenged with improving efficiency by incorporating new technologies and complex biology. Hence, in order to obtain promising candidates, high quality assays are required.
A common trend observed in life science testing over the past several years has been the ever shrinking test volume. Increasing costs of chemical compounds and commonly used solvents has pushed high throughput screening labs towards lower working volumes, specifically in the nanoliter range.