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10 Tips To Improve Your Pipetting Technique
The experts at Artel demonstrate, in detail, how your pipetting technique and the performance of your pipette can be significantly improved.
Viscous Poster
Pipetting Viscous Solutions
The Pipetting Viscous Solutions poster provides guidance on pipetting solutions and helps in understanding that viscosity is the measure of a liquid’s resistance to flow.
Minimize Variability in your NGS assay
This webinar presents methodologies for increasing throughput, lowering costs and improving reproducibility for your automated assays.

Ten Tips for Proper Pipetting

By Carle, B.
Overview Like most recurring or common tasks, pipetting is sometimes taken for granted. But since even minor variation in operating technique can produce measurable errors…

SURVEY REPORT: Data quality, variability, and reproducibility

By Artel
From the Reproducibility Initiative to F1000 Research's Preclinical Reproducibility and Robustness channel, much attention in the life science community has been focused on study reproducibility.…

Minimizing Liquid Delivery Risk: Pipettes as Sources of Error

By Curtis, R.
Liquid delivery is one of the most common processes in life science laboratories, from drug discovery and compound management laboratories to analytical chemistry and genomics/proteomics…

Minimizing Liquid Delivery Risk: Automated Liquid Handlers as Sources of Error

By Albert, K.
The use of automated liquid handling equipment to rapidly test and reproducibly screen thousands of compounds has become an essential component to life science laboratories…

Best Practices for the Use of Micropipets

By Carle, B.
Note: this publication has been modified to fit this page. Download the published version.  Every day, air-displacement pipets are used to quantitatively dispense sample and…

Effect of Liquid Handling Accuracy on Assay Performance

By Hentz, N., Knaide, T.
This study illustrates how optimization of both liquid-handling accuracy and precision is critical to assay performance. The study was designed to examine (1) liquid-handling performance…

DMSO Sample Solution for Liquid Handler Performance Verification

By Parshley, R.
Dimethyl sulfoxide (DMSO) has become one of the most important solvents used for high-throughput screening (HTS) and compound management applications due to its ability to…

Five Good Reasons: the argument for pipetting technique training

By Carle, Bjoern
Liquid handling quality assurance is a critical component of an effective laboratory quality program. While quality assurance efforts in liquid handling typically place much emphasis on pipette calibration, repair, and…

8 Easy Steps for Performing Pipette Preventive Maintenance

By Artel
Pipettes are precision devices that require care for consistent results. Performing preventive maintenance routinely will help to minimize malfunctions and keep your instruments in good operating condition.…

Artel Extreme Pipetting Expedition: Measuring the Impact of Common Environmental Conditions on Laboratory Data Integrity

By Rodrigues, G.
A team of scientists journey to extreme locations to demonstrate how even the most typical laboratory conditions can wreak havoc on pipette accuracy. While pipetting…

Extreme Pipetting IV: It’s Not the Heat, It’s the…

By Rumery, D.; Carle, B.
Pipettes perform exceptionally well in high humidity Fresh on the heels of Mission 3 at the stiflingly hot Death Valley National Park, the Artel Extreme…

Preventing Pandemics – The Global Influenza Threat

By Hentz, N.
Over the years, influenza has taken the lives of millions. While vaccines are helping to reduce the damage caused by the virus there is still…

The Critical Role of Liquid Handling in Effective Assay Transfer

By Albert, K.
Top Tips to Facilitate Assay Transfer Within and Across Laboratories With the life sciences industry racing down the path towards globalization and outsourcing, the importance…

Can You Trust Your Robot?

By Knaide, T.
While robotic liquid handlers have allowed increased testing capabilities in the laboratory, concerns over protocol, accuracy and suitability still remain. Laboratories around the world have turned to…

Optimizing Automated Liquid Handlers

By Yandell, W., Wexler, D.
Using Longitudinal Data to Understand Performance Life science, clinical and IVD manufacturing laboratories have benefited from the recent technological advances in liquid handling instrumentation, from…

Rapid Volume Verification in High-Density Microtiter Plates Using Dual-Dye Photometry

By Knaide, T., Bradshaw, J., Rogers, A., McNally, C., Curtis, R., Spaulding, B.
The dual-dye photometric technology used by Artel's MVS Multichannel Verification System overcomes challenges associated with determining the dispensed volume within each well of a 384-well microtiter…

The Importance of Liquid Handling Quality Assurance Through the Drug Discovery Process

By Hentz, N.
The tug-of-war between quality and productivity is an issue facing all drug discovery companies, competing in a fierce race to bring breakthrough drugs to market…

Multichannel Verification System: A Dual-Dye Photometry System For Performance Verification of Multichannel Delivery Devices

By Bradshaw, J.T., Knaide, T., Rogers, A., Curtis, R.
Artel has developed the MVS Multichannel Verification System, a photometric method for verifying the performance of automated multichannel liquid delivery equipment.  On the basis of…

How It Works: Verifying Liquid Handling Instrumentation Performance

By Rodrigues, G.
Problem: Laboratories often assume that their liquid handling instruments, from pipettes to automated liquid handlers, are operating within specifications. However, because data integrity for applications, from…

Standardizing pipette calibration in a large laboratory organization results in economic and quality gains

By Pou, P.
Large laboratory organizations with many departments find it difficult to allocate responsibility effectively for quality control. While a centralized, top-down approach can simplify regulatory compliance,…

The Effect of One Microliter

By Rodrigues, G.
And Why Microliters Matter Pharmaceutical processes typically take place on the scale of gallons or liters, even tens of thousands of liters.  So why would anyone…

Liquid Delivery Accuracy Advisor: Solutions to Your Liquid Handling Issues

By Rodrigues, G.
It is absolutely critical to verify that the amount of liquid transferred from well-to-well is accurate across the plate, for all steps. Some assumptions, like…

Comparing Calibration Technologies for Liquid Handling Quality Assurance

By Curtis, R., Rodrigues, G.
The use of high-quality precision liquid handling instruments throughout the drug discovery, testing and production processes has tended to give scientists a sense of confidence…

Ratiometric Photometry for Pipette Calibration

By Rodrigues, G.
Method Critical for Low-volume Measurement For Linco Diagnostic Services (www.lincodiagnostics.com), quality assurance is critical. Performing functions such as bioanalytical services and clinical trials for pharmaceutical and biotechnology…

The Role of Automation in Liquid Delivery Quality Assurance

By Rodrigues, G.
The word “calibration” often conjures up negative images, especially in IVD development and manufacturing, where regulations mandate that laboratories and production plants have regular calibration…

Ratiometric Photometry Improves Laboratory Quality Assurance

By Rodrigues, G.
New Methodology Accurately and Precisely Verifies Low Volume Liquid Delivery Laboratories often assume that their liquid handling instruments, from pipettes to automated liquid handlers, are…

Transferability of Pipet Calibrations and Proficiency of Operators: Prerequisites for Method Validations and Method Transfers

By Rodrigues, G., Carle, A.B., Curtis, R.
Data quality and integrity are among the most important issues for any laboratory, and one of the most obvious ways to maintain quality in a…

When Times Are Tough, Train, Train, Train!

By Rodrigues, G., Vaccaro, W.
How to Implement Pipetting Technique Training to Improve Laboratory Quality Staff members are critical laboratory assets. Not only are laboratory technicians directly involved in producing…

Minimizing Liquid Delivery Risk: Pipetting Technique as Source of Error

By Vaccaro, W.
For laboratory quality assurance, all critical tasks must be standardized, including liquid handling. Laboratory liquid handling quality assurance programs commonly focus on pipette calibration, repair and…

Pipette Calibration System Minimizes Pipetting Error, Strengthens Data Integrity

By Curtis, R.
Pipetting microliter volumes of liquid has become one of the most frequently performed laboratory procedures. The speed, convenience and cost benefits of microliter‑volume, air‑displacement pipettes drive…

US Pharmacopeia Proposes Changes to Weighing Chapters

By Rodrigues, G.
Weighing is one of the most fundamental of laboratory tasks, and careful weighing is a central pillar supporting the generation of high-quality laboratory results. New proposals…

CMS Offers EP23 as Risk-Based Option for Clinical QC Plans

By Carle, A.B.
In two memoranda dated November 4, 2011 and March 9, 2012 the US Centers for Medicare and Medicaid Services (CMS) have informed laboratories of their intention to provide a…

When Do Guidelines Become Requirements?

By Rodrigues, G.
MIQE Makes a Difference in PCR A guideline such as Minimum Information for Publication of Quantitative Real-time PCR Experiments (MIQE) is a good example of how a science-based…

New ISO Standard Answers Growing Need for Data Integrity in the Laboratory

By Rodrigues, G.
Technologies often develop more quickly than regulatory agencies can respond. This is especially true in drug discovery and development due to the rapid pace of new…

Taking Control of Your Quality Control

By Rodrigues, G.
Navigating Regulations and Standards for Liquid Delivery Verification Consider a quality control laboratory that processes 10 to 20 samples per day and releases as many…

3 Tips to Aid Assay Transfer

By Keith J. Albert, Ph.D.
These guidelines can improve the success of assay transfers within and between laboratories Ensuring that assays give the same results on different platforms or in…

Optimization of Automated Liquid Handlers

By Keith J. Albert, Ph.D.
Regular Instrument Performance Checks Help Ensure Accurate Reagent Volume Transfer Over the past 20 years, laboratories around the world have been turning to liquid handling robots to…

Climb Every Mountain: Extreme Pipetting I

By Rodrigues, G.
The Effect of Barometric Pressure on Data Integrity One cold day in early winter, a group of scientists prepare to trek to the top of…

Extreme Pipetting II: Thermal Exploration

By Rodrigues, G.; Rumery, D.
The effect of fluid temperature on data integrity After studying the effects of barometric pressure on pipette volumes atop New Hampshire’s Mount Washington—home of the…

Extreme Pipetting III: Death Valley Data

By Rodrigues, G., Rumery, D.
The effect of dry heat on laboratory data As the Artel extreme pipetting expedition team set out for Mission 3, only one thing was certain: it…

Minimizing Liquid Delivery Risk: Laboratory Environmental Conditions as Sources of Error

By Carle, A.B.
Part 1: Barometric Pressure and Thermal Disequilibrium The first and the third article in this series focused on manually operated pipettes as sources of error,…

In Liquid Handling Quality Assurance, All That Matters is Location, Location, Location

By Rodrigues, G.
A number of high-profile drug failures and mushrooming costs have led to growing scrutiny of the pharmaceutical industry. While drug manufacturing has always faced intense…

The Use of A Dual Dye Photometric Calibration Method To Identify Possible Sample Dilution From An Automated Multichannel Liquid-Handling System

By Huijin Dong, Zheng Ouyang, Jane Liu, and Mohammed Jemal
A significant difference between the reported volumes delivered by a fluid-filled automated liquid-handling system with eight stainless steel fixed tips was observed when a gravimetric…

Verifying Liquid Handler Performance for Complex or Non-Aqueous Reagents: A New Approach

By Keith J. Albert, John Thomas Bradshaw, Tanya R. Knaide, and Alexis L. Rogers
Multichannel volume dispensing devices, such as automated liquid handlers, are widely used in drug discovery assays and other high-throughput screening processes. The performance of these…

Importance of Integrating a Volume Verification Method for Liquid Handlers: Applications in Learning Performance Behavior

By Keith J. Albert, John Thomas Bradshaw
Nearly all assays performed within a microtiter plate are volume dependent. In turn, all concentrations of biological and chemical components in these assays, as well…

Determining Dilution Accuracy in Microtiter Plate Assays Using Quantitative Dual-Wavelength Absorbance Method

By John Thomas Bradshaw, Richard H. Curtis, Tanya R. Knaide, and Benjamin W. Spaulding
Dilution-based volume transfer steps are commonly performed for many types of microtiter plate-based assays. Because the exact concentrations of target samples in solution are typically…

Metrological Traceability of In-House Calibrations

By Rodrigues, G.
Equipment calibration is a necessary and common fact of life in regulated laboratories, and the decision on how to calibrate often begins with a simple…

Frequently Asked Questions regarding ISO 8655, pipette calibration, and Artel’s photometric method

By
The answers to these FAQ’s were developed in consultation with Dr. Burkhard Winter of the German Standards Institute DIN, and are based on definitions given…